Assay Development Scientist – Profiling Development

About the Role

At Nomic, we’re building the world’s highest throughput protein profiling platform to help scientists extend lives. As an Assay Development Scientist on the Profiling Development team, you’ll design and optimize high-content proteomic assays that push the capabilities of our core nELISA technology.

You’ll develop scalable, high-throughput assays and the Quality Control (QC) systems to ensure they perform reliably across diverse sample types. From fluorescent signal optimization to complex matrix handling, your work will directly power our ability to profile millions of proteins with precision and speed.

You’ll collaborate closely with teammates across Automation, Data, Software, and Operations — owning method development, troubleshooting, validation, and smooth adoption of new workflows into production.

What You’ll Be Doing

• Assay Development & QC – Design, validate, and optimize proteomic assays and corresponding QC strategies to ensure robustness, sensitivity, and scalability across nELISA workflows.
• Fluorescent Labeling Optimization – Evaluate and improve conjugation chemistries, dye performance, and amplification strategies to maximize signal quality in complex biological matrices.
• Detection Method Optimization – Characterize and enhance flow cytometry and other optical detection techniques to meet performance targets and spectral requirements.
• Sample Diversity & Integration – Develop and validate protocols for diverse sample types, working with Automation to scale and integrate them into high-throughput workflows.
• Cross-functional Collaboration – Drive assay development from concept through deployment in a collaborative, fast-paced environment. Support root cause investigations, continuous improvements, and protocol handoffs to the Profiling team.

About You

You’re passionate about enabling high-impact science through rigorous, scalable assay design.

You enjoy hands-on experimentation and bring a detail-oriented, analytical mindset to solving complex challenges.

You thrive in cross-functional teams and take initiative to move work forward collaboratively.

You care deeply about data quality, reproducibility, and building assays that stand up to real-world variation.

You’re comfortable navigating ambiguity and excited to contribute to a platform that’s transforming proteomics.

What You Bring

• Ph.D. or M.Sc in Bio-Engineering or other biotechnology-related field, with 5+ years of hands-on experience in assay development — ideally within a biotech or life sciences company.
• Strong technical foundation in fluorescence-based bioassays, including experience with conjugation chemistry, and fluorescent labeling strategies.
• Proficiency with techniques such as ELISA, flow cytometry, bead-based assays, bioconjugation and purification, spectroscopy, or molecular biology.
• Experience working with complex biological samples and developing assays that account for matrix variability and real-world conditions.
• Familiarity with biotech R&D or manufacturing standards (e.g., GLP, GMP) and comfort with analyzing assay performance data to drive improvements.
• Clear, collaborative communication and a track record of managing projects across diverse teams.

About Nomic

Nomic was founded with a simple but ambitious goal: to make biology easier to measure. We developed nELISA, a breakthrough proteomic platform that combines DNA nanotechnology, high-dimensional flow cytometry, lab automation, and machine learning. Our platform can process over 2.5 million samples per year — generating 500 million protein assays — and is used by top-tier pharma companies and drug discovery groups.

Backed by $42M in Series B funding, we’re scaling fast. We’ve profiled more than 60 million proteins from over 400,000 samples, and our work is enabling discoveries that help extend lives.

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